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Symbol Name ID |
Dtx1
deltex 1, E3 ubiquitin ligase MGI:1352744 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
decreased thymocyte apoptosis |
increased B cell proliferation |
decreased T cell proliferation |
increased T cell proliferation |
abnormal thymocyte activation |
spleen hyperplasia |
decreased marginal zone B cell number |
abnormal lymphocyte morphology |
abnormal lymphocyte physiology |
abnormal T cell activation |
abnormal regulatory T cell physiology |
increased interferon-gamma secretion |
decreased interleukin-2 secretion |
increased interleukin-2 secretion |
increased interleukin-4 secretion |
abnormal T cell anergy |
increased autoantibody level |
increased anti-double stranded DNA antibody level |
increased anti-histone antibody level |
liver inflammation |
glomerulonephritis |
lung inflammation |
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| Availability | Mouse Genotype | |||||||||||||||||||||||
| Dtx1tm1.2Mzl/Dtx1tm1.2Mzl | ||||||||||||||||||||||||
| Dtx1tm1Mjb/Dtx1tm1Mjb | * | |||||||||||||||||||||||
| Tg(Cd4-Dtx1)1Mzl/? | ||||||||||||||||||||||||
| Dtx1tm1.1Mzl/Dtx1tm1.1Mzl Tg(Cd4-cre)1Cwi/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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